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Expertise in Alzheimer's Disease

Clinical and Translational Science

Researchers in clinical and translational science at Indiana University School of Medicine test new methods to diagnose, treat and prevent Alzheimer’s disease. Much of this clinical research is led by investigators at the Indiana Alzheimer's Disease Research Center and in the Department of Neurology, who work to translate research advances into improved diagnosis and care for people with Alzheimer’s disease.

One of the largest studies on Alzheimer’s disease in people under 65 years of age, the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS), is underway at IU School of Medicine to develop clinical and biomarker measures for future clinical and research use for this devastating disease.

Through the Center for Neuroimaging, researchers use advanced brain imaging techniques to detect Alzheimer’s disease before a patient begins to show symptoms. Imaging also helps assess whether potential drugs work by measuring if they clear plaques and tangles or if they slow atrophy or loss of brain volume.

Together, advanced imaging, biomarkers from blood or cerebrospinal fluid, genomics and cognitive testing provide the foundation for an emerging precision medicine of Alzheimer’s disease and related dementias.


The Longitudinal Early-Onset Alzheimer’s Disease Study assesses clinical, cognitive, imaging, biomarker and genetic characteristics of people with early-onset Alzheimer's disease.


The National Centralized Repository for Alzheimer’s Disease and Related Dementias provides critical access to more than half a million biological samples from people with Alzheimer’s disease.

Clinical Research

Clinical trials conducted through neurologists at IU School of Medicine test the safety and effectiveness of new treatments and therapeutics designed to prevent, diagnose and treat Alzheimer's disease and related dementia.

Interview an Alzheimer's Disease Expert

Schedule an interview with an IU School of Medicine faculty member or request materials and resources about Alzheimer’s disease research by contacting the IU School of Medicine media relations team.