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Indiana University School of Medicine
Indiana University School of Medicine
Neurological Surgery

Neurological Surgery Clinical Research

Faculty investigators in the Department of Neurological Surgery at Indiana University School of Medicine lead more than 20 clinical trials that specialize in neurosurgical clinical research of various disease states, such as hydrocephalus, epilepsy, cancers of the brain, traumatic brain injury and brain aneurysms. Many of these trials are conducted in collaboration with research institutions across the country.

Clinical trials are research studies that involve people and are conducted to evaluate a new medical treatment, drug or medical device. They are designed to find new and improved ways to diagnose, treat or prevent different diseases. Researchers depend on patient volunteers to participate in clinical trials to determine whether a new drug or procedure is more effective compared to the current or standard method. Besides improving their own health, participants can make a life-saving difference in lives of others with similar conditions.

47 patients enrolled in adult neurosurgery trials
24 clinical research trials
164 patients enrolled in pediatric neurosurgery trials

Active Clinical Research Investigations

PENS: A Placebo-Controlled Effectiveness in iNPH Shunting
Condition: Hydrocephalus.
Principal Investigator: Jesse Savage, MD

Bioengineering Strategies to Investigate Treatment Failure in Hydrocephalus
Principal Investigator: Rabia Qaiser, MD

HCRN: Hydrocephalus Clinical Research Network (HCRN) Core Data Project: Characterizing Patient Populations within the HCRN
Principal Investigator: Jignesh Tailor, MD

Role of Inflammatory Mediators in Congenital Hydrocephalus
Principal Investigator: Jignesh Tailor, MD

Outcomes of Focused Ultrasound (FUS) Thalamotomy and Pallidotomy
Principal Investigator: Thomas Witt, MD

MRgLITT: MRI-Guided Laser Interstitial Thermal Therapy (MRgLITT) Registry
Condition: Epilepsy
Principal Investigator: Jignesh Tailor, MD

Predicting Seizure Responsiveness to Neuromodulation Using Connectomic Profiling [Vagus Nerve Stimulated (VNS) Study]
Condition: Epilepsy
Principal Investigator: Jignesh Tailor, MD

Dissecting the cellular heterogeneity of epileptogenic zones
Condition: Epilepsy
Principal Investigator: Jignesh Tailor, MD

CPRN: Cerebral Palsy Research Network Registry
Principal Investigator: Saul Wilson, MD

sTaRT: A Multicenter Observational Study of GammaTile™ Surgically Targeted RadiationTherapy
Principal Investigator: Mitesh Shah, MD

New Mets: Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy(STaRT) with Gamme Tile, Newly Diagnosed Glioblastoma 
Principal Investigator: Angela Richardson, MD, PhD

Feasibility Study of Resection and GammaTile® Followed by Concomitant External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ in Newly Diagnosed Glioblastoma (GBM)
Principal Investigator: Mitesh Shah, MD

An Observational Study: Surgeon experience using the Novel Pulse Control Setting on Sonopet including video demonstration of use
Principal Investigator: Mitesh Shah, MD

Track TBI/ISTAT: Clinical Evaluation of the i-STAT TBI Test
Condition: Traumatic Brain Injury.
Principal Investigator: Jamie Bradbury, MD

EVOLVE: Endovascular Treatment Of Wide-Neck Aneurysms, an Evaluation of Safety, and Effectiveness of Stryker Surpass Evolve Flow Diverter System
Principal Investigator: Bradley Bohnstedt, MD
*No longer enrolling patients

RAGE: Ruptured Aneurysms Treated with Hydrogel Coils
Condition: Ruptured Brain aneurysm. 
Principal Investigator: Bradley Bohnstedt, MD
*No longer enrolling patients

SUCCESS: Success in Comaneci-assist Coils Embolization Surveillance Study
Condition: wide-necked ruptured and/or unruptured intracranial aneurysms. 
Principal Investigator: Bradley Bohnstedt, MD 

CITADEL: The Citadel Embolization Device Study
Condition: Brain aneurysm. 
Principal Investigator: Bradley Bohnstedt, MD

THUNDER: Acute Ischemic Stroke Study with the Penumbra System® including Thunderbolt™ Aspiration Tubing
Principal Investigator: Bradley Bohnstedt, MD

Safety and Tolerability of GTX-104 (Nimodipine Injection for IV Infusion) Compared with Oral Nimodipine in Patients Hospitalized for Aneurysmal Subarachnoid Hemorrhage (aSAH): a Prospective, Randomized Trial. Condition: Aneurysmal Subarachnoid Hemorrhage (aSAH).
Principal Investigator: Bradley Bohnstedt, MD

Multisite Review for the Safety and Efficacy of the Surpass Evolve Diverter in Patients Greater than 6 Months Post-Implantation. 
Principal Investigator: Bradley Bohnstedt, MD

The Park-Reeves Syringomyelia Research Consortium
Principal Investigator: Laurie Ackerman, MD

The Genetics of Chiari Malformations
Principal Investigator: Laurie Ackerman, MD

Multi-Center, Observational Study for Medtronic Spine Implantable Devices
Principal Investigator: David Stockwell, MD