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Clinical Core

The IADRC Clinical Core supports the overall mission of Indiana University School of Medicine to improve early detection of neurodegenerative diseases at the transition from normal cognition to prodromal stages by providing researchers with high quality clinical, imaging, biomarker and neuropathological data in Alzheimer’s disease and hereditary dementias.

The IADRC Clinical Core recruits and longitudinally follows a diverse cohort of research participants and collects standardized clinical, neuropsychological and biomarker data to support innovative interdisciplinary research locally, nationally and internationally. Critical to the function of the Indiana Alzheimer’s Disease Research Center, this core identifies and clinically characterizes research participants in the presymptomatic and prodromal stages of dementia, including those with MCI, Alzheimer’s disease, and non-Alzheimer’s disease. The core also collects data on healthy controls.

In furtherance of the center’s overarching goal of supporting the broader dementia research endeavor, the IADRC Clinical Core shares resources and data and collaborates regionally, nationally and internationally with other NIA-Designated Alzheimer’s Disease Research Centers and the National Alzheimer’s Coordinating Center (NACC) as well as with the Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer’s Network (DIAN), National Centralized Repository for Alzheimer’s Disease (NCRAD), the Alzheimer’s Disease Cooperative Study (ADCS), the Alzheimer’s Association research programs, and participates in innovative industry-sponsored investigational new drug trials.


  • Identify, recruit, and longitudinally assess participants 1) who are asymptomatic, or early symptomatic families with hereditary Alzheimer’s disease, 2) with early symptomatic stages of late onset Alzheimer’s disease, and 3) those with other dementias or mixed dementias
  • Obtain and facilitate the storage of neuroimaging data and samples from our research participants while promoting and supporting cutting edge research pertaining to dementia and cognitive aging
  • Collaborate with other IADRC cores to provide education and training opportunities to researchers and trainees at all levels and to educate and support affected participants, family members, and the community at large