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Clinical Pharmacology Analytical Core

Detailed understanding of drug disposition and factors affecting this process is important to guide preclinical drug discovery and development and in optimizing available drug therapies. The Clinical Pharmacology Analytical Core specifically focuses on providing scientific and technical services to help investigators in their preclinical and clinical drug metabolism and pharmacokinetic studies. To support these activities, the core utilizes state-of-the-art LC-MS/MS methods to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide variety of biological samples (plasma, urine, tissues, media, etc.). The core provides investigators with detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, drug purity verification, and drug stability. The Clinical Pharmacology Analytical Core is the only analytical core on campus that offers a unique combination of extensive expertise on in vitro and in vivo drug metabolism, including stereoselective metabolism, drug-drug interactions, and pharmacokinetics (PK).


  • Method development to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide range of biological matrices utilizing HPLC-MS/MS
  • Drug purity verification and stability
  • In vitro metabolic stability
  • Formulation solubility and stability
  • Protein binding
  • In vivo pharmacokinetics
  • Non compartmental analysis

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Andi Masters, MS

Core Director


4934-Desta, Zeruesenay

Zeruesenay Desta, PhD

Scientific Director

Read Bio Zeruesenay Desta, PhD

Contact the Clinical Pharmacology Analytical Core

Email the core director